Pair Name	Brassinolid, Doxorubicin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	APC	hsa324
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Activity	CASP3	hsa836
	Down-regulation	Expression	JUN	hsa3725
	Down-regulation	Expression	MMP1	hsa4312
	Down-regulation	Expression	MMP26	hsa56547
	Down-regulation	Expression	MMP7	hsa4316
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	NANOG	hsa79923
	Up-regulation	Expression	POU5F1	hsa5460
	Down-regulation	Expression	SOX9	hsa6662
	Up-regulation	Expression	VEGFA	hsa7422
In Vitro Model	NCI-H69	Lung small cell carcinoma	Homo sapiens (Human)	CVCL_1579
Result	These data indicate that EB, a natural product with widespread occurrence in plants, is pharmacologically active in both drug-sensitive and drug-resistant SCLC cells and acts through the Wnt signaling pathway.